Innovations in Biotechnology applied to regenerative medicine

Fondazione Poliambulanza Istituto Ospedaliero (CREM)-BRESCIA

2 Years
Degree Classes
LM-9 (Biotecnologie mediche, veterinarie e farmaceutiche)

Study Plan


The program is a 2-year course and made of a total of 120 credits. One credit (CFU) corresponds to 25 hours of total commitment per student. The breakdown of the total time commitment for each credit between assisted teaching and individual study is determined as follows:

  • 1 credit lecture= 8 hours of lecture + 17 hours of individual study
  • 1 credit laboratory=25 hours of assisted teaching
  • 1 credit curricular internship= 25 hours of training activities (at the institution/industry
    where the internship is carried out)
  • 1 credit final exam= 25 hours of individual study

The student acquires credits after passing the exam or successfully completing other forms of learning comprehension.

Year 1

  • Stem cell biology + LAB
  • Cellular secretome: components and properties + LAB 
  • Stem cell research: an anthropological question
  • Tissue regeneration during evolution: from invertebrates to vertebrates

  • Genome editing and stem cell reprogramming
  • Mechanobiology and signal transduction 
  • Omic profiling of stem cells

  • Basics of imaging and spectroscopy 
  • Fundamentals of programming for biological sciences 
  • Machine learning for biological sciences

  • Cellular basis of degenerative processes + LAB
  • Cellular basis of regenerative processes 
  • Environmental toxicants in tissue degeneration 
  • Inflammation in tissue degeneration (inflammaging)

  • Nanomaterials
  • Principles of biomaterial engineering and scaffold design
  • Science at the nanoscale: physics and chemistry of surfaces

  • Academic grant writing for regenerative medicine applications: salient features of a successful proposal + LAB
  • Critical reasoning - analysis of current science + LAB
  • The processes of patent application + LAB

  • Basics of applied economics
  • Introduction to Ethics in clinical trials: ethical committees
  • Regulatory aspects in ATMPS and beyond
  • Technology transfer in biotechnology translating into the clinics: research processes and phases of clinical trials

  • Scientific English 1

*For mother tongue Italian students, Advanced English (2 CFU)

Seminar on theological issues (in Y1 or Y2)

Year 2

  • Laboratory safety

  • Advanced therapies in immune-related diseases 
  • Animal models for regenerative medicine 
  • Microfluidic-based models: organ on-chip, human on-chip, bioreactors 
  • Modeling neurodegenerative disorders
  • Statistics and mathematical models in biology

  • Cell culture LAB: cell isolation and culture
  • Molecular biology LAB

  • Advances in imaging and spectroscopy LAB 
  • Animal experimentation 
  • Flow cytometry LAB 
  • Imaging in cell biology: techniques, technology and tools LAB

  • Scientific English 2

  • Internships abroad or in Italy

  • Experimental thesis


Attendance is required for all activities (lectures and laboratory). In order to be admitted for
exams students must have attended at least 65% of the lectures in the classroom and at least 80% of the laboratory activities. Attendance will be verified at the discretion of the Lecturer/Professor.